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Adults and children 12 years of age and older: take 1 tablet every 12 hours, not more than 2 tablets in 24 hours unless directed by a doctor.

INDICATIONS AND USAGE: Karbinal ER (carbinoxamine maleate) Extended-release Oral Suspension is an H1 receptor antagonist indicated for the symptomatic treatment of: Seasonal and perennial allergic rhinitis (1) Vasomotor rhinitis (1) Allergic conjunctivitis due to inhalant allergens and foods (1) Mild, uncomplicated allergic skin manifestations of urticaria and angioedema (1) Dermatographism (1) As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled (1) Amelioration of the severity of allergic reactions to blood or plasma (1) DOSAGE AND ADMINISTRATION The dosage of Karbinal ER should be individualized based on the severity of the condition and the response of the patient.

A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.

Claritin-D 24 hour (10mg loratadine 240mg psuedophedrine) Dosing (Adult): one tablet po qd. Approval: 2013 Mechanism of Action: Carbinoxamine is an H1 receptor antagonist (antihistamine) that exhibits anticholinergic (drying) and sedative properties.

Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.

Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.

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