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In fact, according to a 2014 review paper published in the , the median number of pivotal trials performed prior to FDA drug approval is two, and over one-third of newly approved pharmaceuticals are brought to market on the basis of only a single pivotal trial.

As clinical research into the therapeutic value of cannabinoids has proliferated so too has investigators' understanding of cannabis' remarkable capacity to combat disease.

Foreword Endocannabinoid System Why Medical Cannabis Alzheimer's Disease ALS Chronic Pain Diabetes Mellitus Dystonia Epilepsy Fibromyalgia GI Disorders Gliomas/Cancer Hepatitis C HIV Huntington's Disease Hypertension Incontinence Migraine MRSA Multiple Sclerosis Osteoporosis Parkinson's Disease Post-Traumatic Stress Pruritus Rheumatoid Arthritis Sleep Apnea Tourette Syndrome Humans have cultivated and consumed the flowering tops of the female cannabis plant, colloquially known as marijuana, since virtually the beginning of recorded history. In 2008, archeologists in Central Asia discovered over two pounds of cannabis in the 2,700-year-old grave of an ancient shaman.

E have been recovered in northern China, and the plant's use as a medicinal and mood altering agent date back nearly as far.

To date, over 140 gold-standard clinical trials exist examining the safety and efficacy of cannabis or individual cannabinoids in some 8,000 patients.

This classification, which categorizes the plant alongside heroin, defines cannabis and its dozens of distinct cannabinoids as possessing 'a high potential for abuse, ... [and] a lack of accepted safety for the use of the drug ...

After scientists conducted extensive testing on the material's potency, they affirmed, "[T]he most probable conclusion ...

is that [ancient] culture[s] cultivated cannabis for pharmaceutical, psychoactive, and divinatory purposes." Modern cultures continue to indulge in the consumption of cannabis for these same purposes, despite a decades-long, virtual worldwide ban on the plant's cultivation and use.

"States with medical cannabis laws had a 24.8 percent lower mean annual opioid overdose mortality rate compared with states without medical cannabis laws," researchers concluded.

Specifically, they determined that overdose deaths from opioids decreased by an average of 20 percent one year after the law's implementation, 25 percent by two years, and up to 33 percent by years five and six.

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